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Chromatography Troubleshooting

Symptom-first guides for HPLC, UHPLC, GC and LC-MS - what the instrument is telling you, how to isolate the cause, and what to change.

How to Use Them

Start From the Symptom, Not the Theory

Most troubleshooting material is organized the way a textbook is: by component, by principle, by chapter. That is the wrong index for someone standing at an instrument at four in the afternoon. You do not know yet that it is the guard column - that is the thing you are trying to find out.

So the library is organized by what you can actually observe. Pick the category that matches what the instrument is doing, find the symptom, and follow it back through the causes worth ruling out first.

The guides are written by our scientists and are open to everyone. No account, no sign-up, no email wall - a troubleshooting guide behind a form is a troubleshooting guide nobody reads in time.

Free to read, indexed by symptom, and written for the moment the run is already going wrong.

What a Guide Contains

Written to Be Used Standing Up

Each guide follows the same shape, so you are not re-learning the format every time you open one.

The Symptom, Described Precisely

What the instrument is doing, in the terms you would use to describe it to a colleague - not a diagnosis you are not yet in a position to make.

Causes, in the Order Worth Checking

The likely causes ranked by how cheap they are to rule out, so the five-minute check comes before the one that costs you a column.

Something You Can Change

Each cause ends in an action - a setting, a part, a preparation step. A guide that stops at the explanation has not finished the job.

Troubleshoot It With the Chat Open.

The guides stay free either way. Inside ChemITrust AI you can also ask the follow-up question, dictate what you observed, and keep the run beside the notes that explain it.